Lipid phosphate phosphohydrolase. One route of LPA degradation is de-phosphorylation.

Lipid phosphate phosphohydrolase. Type 2 lipid phosphate phosphohydrolases (LPPs), formerly known as phosphatidic acid phosphatases (PAPs), are enzymes that catalyse the hydrolysis of a variety of lipid phosphate mono-esters, including lysophosphatidic acid (LPA), PA, diacylglycerolpyrophosphate, S1P and ceramide 1-phosphate (C-1-P). Because PAP2 degrades sphingosine-1-phosphate (S1P) and ceramide-1-phosphate in addition to PA and lyso-PA, it has been renamed lipid phosphate phosphohydrolase (LPP). May 23, 2002 · Although several lipid phosphate phosphatases with broad substrate specificity for phosphorylated lipids, including S1P and glycerolipids, have been cloned and characterized in mammals (Fig. Mammalian LPPs consist of three isoforms: LPP1, LPP2, and LPP3. May 1, 2009 · Lipid phosphate phosphohydrolase activity of selected organs of Ppap2atr/tr and Ppap2a+/+ mice The lipid phosphate phosphohydrolase activity of Ppap2a+/+ and Ppap2atr/tr mice was measured as the ability of organ homogenates to release [32 P]H 3 PO 4 from 32 P-labeled LPA or PA in a Triton X-100 mixed micelles assay. The known mammalian LPPs are shown together with the other names that have been applied to them. We report here the development of a mouse wherein the LPP1 gene (Ppap2a) was disrupted. Oct 23, 2008 · Lipid phosphate phosphatases (LPPs) regulate cell signaling by modifying the concentrations of lipid phosphates versus their dephosphorylated products. Because the precise biological functions of these phosphohydrolases are not known, we propose to rename the PAP-2 family (Table I) as lipid phosphate phosphohydrolases (LPPs). They share highly conserved catalytic domains and catalyze the dephosphorylation of a variety of lipid phosphates, including phosphatidate, lysophosphatidate (LPA), sphingosine 1-phosphate (S1P), ceramide 1-phosphate, and diacylglycerol pyrophosphate. Nov 1, 2015 · Lipid phosphate phosphatases (LPPs) are a group of enzymes that belong to a phosphatase/phosphotransferase family. LPP products (monoacylglycerol or sphingosine) are taken up by cells Lipid phosphate phosphatases (LPP) are integral membrane proteins with broad substrate specificity that dephosphorylate lipid substrates including phosphatidic acid, lysophosphatidic acid, ceramide 1-phosphate, sphingosine 1-phosphate, and . Feb 5, 2015 · Lipid phosphate phosphatases (LPPs) are a group of enzymes that belong to a phosphatase/phosphotransferase family. May 1, 2009 · LPA (lysophosphatidic acid) is a lipid mediator that stimulates cell proliferation and growth, and is involved in physiological and pathological processes such as wound healing, platelet activation, angiogenesis and the growth of tumours. Abstract Lipid phosphate phosphatases (LPPs) regulate cell signaling by modifying the concentrations of lipid phosphates versus their dephosphorylated products. The ecto-activity regulates the availability of extracellular lysophosphatidate (LPA) and sphingosine 1-phosphate (S1P) and thereby signaling by their respective receptors. Dec 9, 2008 · Lipid phosphate phosphatases (LPPs) regulate cell signaling by modifying the concentrations of lipid phosphates versus their dephosphorylated products. 3) [39], experiments using tissue homogenates [60] and whole cells [37] suggested the existence of a phosphohydrolase with high specificity for S1P. One route of LPA degradation is de-phosphorylation. A candidate enzyme is the integral membrane exophosphatase lipid phosphate phosphohydrolase type 1 (LPP1). g0pmq 1tc77 qp4x7 uxx it5 pmawb anr81 vgxok 5jtyu vn1cvp